Bronchospheres with Functioning Cilia
Bronchial cells from a biopsy of a patient with cystic fibrosis were propagated as conditionally reprogrammed cells (CRCs). The CRCs were then placed in organoid culture where they formed an organized, well-differentiated epithelium (bronchospheres) with synchronized movement of cilia.
Immortalization of Epithelial Cells and Methods of Use (new window), U.S. Patent No. 11,001,808 Filed on April 4, 2018. Abstract: The present invention is directed towards methods of culturing non-keratinocyte epithelial cells, with the methods comprising culturing non-keratinocyte epithelial cells in the presence of feeder cells and a calcium-containing medium while inhibiting the activity of Rho kinase (ROCK) in the feeder cell, the non-keratinocyte epithelial cells or both during culturing.
Use of Artemisinin for Treating Tumors Induced by Oncogenic Viruses and for Treating Viral Infections (new window), U.S. Patent Application No. 13/777,244. Filed on February 26, 2013. Abstract: In certain aspects, the invention relates to methods of treating proliferative cervical disorders (such as cervical cancer and cervical dysplasia) and treating virus infection by administering artemisinin-related compounds. In certain aspects, the invention relates to methods of treating a tumor induced by an oncogenic virus, methods of killing or inhibiting a squamous cell carcinoma, and methods of inhibiting the replication of a virus, by administering artemisinin-related compounds.
Protecting Against Canine Oral Papillomavirus (new window), U.S. Patent No. 5,874,089. Filed on October 1, 1996. Abstract: Recombinantly produced L1 major capsid proteins which mimic conformational naturalizing epitopes on human and animal papilloma virions including canine and equine papilloma virions are provided. These recombinant proteins are useful as vaccines for conferring protection against papillomavirus infection. Antibodies to the recombinant protein are also provided. Such antibodies are useful in the diagnosis and treatment of viral infection.
Human Papillomavirus Genes and Their Use in Gene Therapy (new window), U.S. Patent No. 5,376,542. Filed on April 27, 1992. Abstract: A process of immortalizing cells with isolated HPV-16, 18, 31, 33 or 35 E6 and E7 genes or the E7 gene alone to produce non tumorigenic immortalized cell lines which retain the differentiated phenotypic characteristics of the parent cells.