Current Publications

Jiang S, Wang J, Yang C, Tan R, Hou J, Shi Y, Zhang H, Ma S, Wang J, Zhang M, Philips G, Li Z, Ma J, Yu W, Wang G, Wu Y, Schlegel R, Wang H, Cao S, Guo J, Liu X, Dang Y. Continuous culture of urine-derived bladder cancer cells for precision medicine. Protein & Cell. July 25, 2019.

Allen C, Lee S, Norberg S, Kovalovsky D, Ye H, Clavijo P, Hu-Lieskovan S, Schlegel R, Schlom J, Strauss J, Gulley J, Trepel J, Hinrichs C. Safety and clinical activity of PD-L1 blockade in patients with aggressive recurrent respiratory papillomatosis. Journal for Immuno Therapy of Cancer. Vol 7, Article number: 119 (May 03, 2019).

Kettunen K, Boström PJ, Lamminen T, Heinosalo T, West G, Saarinen I, Kaipio K, Rantala J, Albanese C, Poutanen M, Taimen P. Personalized Drug Sensitivity Screening for Bladder Cancer Using Conditionally ReprogrammedPatient-derived Cells. Eur Urol. 2019 Jun 27. pii: S0302-2838(19)30501-9. doi: 10.1016/j.eururo.2019.06.016. [Epub ahead of print].

Baydyuk M, Cha D, Hu J, Yamazaki R, Miller E, Smith V, Kelly K, Huang J. Tracking the evolution of CNS remyelinating lesion in mice with neutral red dye. PNAS first published June 24, 2019

Su S. Di Poto C, Roy R, Liu X, Cui W, Kroemer A, Ressom H. Long-term culture and characterization of patient-derived primary hepatocytes using conditional reprogramming. Exp Biol Med (Maywood). 2019 Jun 11:1535370219855398. doi: 10.1177/1535370219855398. [Epub ahead of print]

Mondal A, Ma A, Li G, Krawczyk E, Yuan R, Lu J, Schlegel R, Stamatakis L, Kowalczyk K, Philips G, Pan C, Liu X. Fidelity of a PDX-CR model for bladder cancer. Biochem Biophys Res Commun. 2019 Jul 11. pii: S0006-291X(19)31325-7. doi: 10.1016/j.bbrc.2019.06.165. [Epub ahead of print]. 

Luo Y, Chen L, Wang G, Qian G, Liu X, Xiao Y, Wang X, Qian K. PPARα gene is a diagnostic and prognostic biomarker in clear cell renal cell  carcinoma by integrated bioinformatics analysis. J Cancer. 2019 May 22;10(10):2319-2331. doi: 10.7150/jca.29178. eCollection 2019.

Cheng S, Qian K, Wang Y, Wang G, Liu X, Xiao Y, Wang X. PPARγ inhibition regulates the cell cycle, proliferation and motility of bladder cancer cells. J Cell Mol Med. 2019 May;23(5):3724-3736. doi: 10.1111/jcmm.14280. Epub 2019 Mar 25.

Wang L, Chen S, Luo Y, Yuan L, Peng T, Qian K, Liu X, Xiao Y, Wang X. Establishing a prediction model for prostate cancer bone metastasis. Int J Biol Sci. 2019; 15(1): 208–220. Published online 2019 Jan 1. doi: 10.7150/ijbs.27537

Wang L, Chen S, Luo Y, Yuan L, Peng T, Qian K, Liu X, Xiao Y, Wang X. Identification of several cell cycle relevant genes highly correlated with the progression and prognosis of human bladder urothelial tumor. J Cell Physiol. 2019 Jan 7. doi: 10.1002/jcp.28023. [Epub ahead of print].

Li Z, Liao J, Yang Z, Choi EY, Lapidus RGLiu X, Cullen KJ, Dan HCo-targeting EGFR and IKKβ/NF-κB signalling pathways in head and neck squamous cellcarcinoma: a potential novel therapy for head and neck squamous cell cancer. Br J Cancer. 2018 Dec 26. doi: 10.1038/s41416-018-0351-z. [Epub ahead of print]

Wang H, Lin X, Luo Y, Sun S, Tian X, Sun Y, Zhang S, Chen J, Zhang J, Liu X, Liu H, Gong Y, Xie C. α-PD-L1 mAb enhances the abscopal effect of hypo-fractionated radiation by attenuating PD-L1expression and inducing CD8+ T-cell infiltration. Immunotherapy. 2018 Dec 4. doi: 10.2217/imt-2018-0049. [Epub ahead of print]

Ge Q, Lu M, Ju L, Qian K, Wang G, Wu CL, Liu X, Xiao Y, Wang X. miR-4324-RACGAP1-STAT3-ESR1 feedback loop inhibits proliferation and metastasis of bladdercancer. Int J Cancer. 2018 Dec 3. doi: 10.1002/ijc.32036. [Epub ahead of print]

Wang Y, Chen L, Wang G, Cheng S, Qian K, Liu XWu CL, Xiao Y, Wang X. Fifteen hub genes associated with progression and prognosis of clear cell renal cell carcinoma identified by coexpression analysis. J Cell Physiol. 2018 Nov 11. doi: 10.1002/jcp.27692. [Epub ahead of print]

Weitao Lin, Yip Y, Jia L, Deng W, Zheng H, Dai W, Ko J, Lo KW, Chung G, Yip K, Lee S, Kwan J, Zhang J, Liu T, Chan J, Kwong D, Lee V, Nicholls J, Busson P, Liu XChiang A, Hui K, Kwok H, Cheung S, Cheung Y, Chan C, Li B, Cheung A, Hau P, Zhou Y, Tsang C, Middeldorp J, Chen H, Lung M, Tsao S. Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma. Nature Communications. 2018 Nov 7. Vol. 9 Art. Nu: 4663 [Epub ahead of print]

Lu M, Ge Q, Wang G, Luo Y, Wang X, Jiang W, Liu X, Wu CL, Xiao Y, Wang X. CIRBP is a novel oncogene in human bladder cancer inducing expression of HIF-1α. Cell Death & Disease. 2018 Oct 12. Vol. 9, Art. Nu: 1046 [Epub ahead of print]

Xiong Y, Yuan L, Chen L, Zhu Y, Zhang S, Liu X, Xiao Y, Wang. Identifying a Novel Biomarker TOP2A of Clear Cell Renal Cell Carcinoma (ccRCC) Associatedwith Smoking by Co-Expression Network Analysis. J Cancer. 2018 Oct 10;9(21):3912-3922. doi: 10.7150/jca.25900. eCollection 2018.

You C, Zhang S, Sun Y, Zhang S, Tang G, Tang F, Liu X, Xiao Y, Zhang J, Gong Y, Xie C. β-catenin decreases acquired TRAIL resistance in non-small-cell lung cancer cells by regulating the redistribution of death receptors. Int J Oncol. 2018 Aug 21. doi: 10.3892/ijo.2018.4529. [Epub ahead of print]

Rosko L, Smith V, Yamazaki R, Huang JOligodendrocyte Bioenergetics in Health and Disease. Neuroscientist. 2018 Aug 20:1073858418793077. doi: 10.1177/1073858418793077. [Epub ahead of print] PMID: 30122106 DOI: 10.1177/1073858418793077

Yip Y, Lin W, Deng W, Jia L, Lo K, Busson P, Vérillaud B, Liu X, Tsang C, Lung M, Tsao SW. Establishment of a nasopharyngeal carcinoma cell line capable of undergoing lytic Epstein-Barr virus reactivation. Lab Invest. 2018 Aug;98(8):1093-1104. doi: 10.1038/s41374-018-0034-7. Epub 2018 May 16.

Alkhilaiwi F, Wang L, Zhou D,Raudsepp T, Ghosh S, Paul S, Palechor-Ceron N, Brandt S, Luff J, Liu X, Schlegel R, Yuan H. Long-term expansion of primary equine keratinocytes that maintain the ability to differentiate into stratified epidermis. Stem Cell Res Ther. 2018 Jul 4;9(1):181. doi: 10.1186/s13287-018-0918-x.

Mondal A, Zhou H, Horikawa I, Suprynowicz F, Li G, Dakic A, Rosenthal B, Ye L, Harris C, Schlegel R, Liu X. Δ133p53α, a natural p53 isoform, contributes to conditional reprogramming and long-term proliferation of primary epithelial cells. Cell Death Dis. 2018 Jul 3;9(7):750. doi: 10.1038/s41419-018-0767-7.

Sun Y, Miao H, Ma S, Zhang L, You C, Tang F, Yang C, Tian X, Wang F, Luo Y, Lin X, Wang H, Li C, Li Z, Yu H, Liu X, Xiao Y, Gong Y, Zhang J, Quan H, Xie C. FePt-Cys nanoparticles induce ROS-dependent cell toxicity, and enhance chemo-radiation sensitivity of NSCLC cells in vivo and in vitroCancer Lett. 2018 Apr 1;418:27-40. doi: 10.1016/j.canlet.2018.01.024. Epub 2018 Jan 11.

Correa BRS, Hu J, Penalva LOF, Schlegel R, Rimm DL, Galante PAF, Agarwal S. Patient-derived conditionally reprogrammed cells maintain intra-tumor genetic heterogeneity. Sci Rep. 2018 Mar 6;8(1):4097. doi: 10.1038/s41598-018-22427-1. PMID: 29511269. PMCID: PMC5840339

Yuan L, Zeng G, Chen L, Wang G, Wang X, Cao X, Lu M, Liu X, Qian G, Xiao Y, Wang X. Identification of key genes and pathways in human clear cell renal cell carcinoma (ccRCC) by co-expression analysisInt J Biol Sci. 2018 Feb 12;14(3):266-279. doi: 10.7150/ijbs.23574. eCollection 2018.

You C, Sun Y, Zhang S, Tang G, Zhang N, Li C, Tian X, Ma S, Luo Y, Sun W, Wang F, Liu X, Xiao Y, Gong Y, Zhang J, Xie C. Trichosanthin enhances sensitivity of non-small cell lung cancer (NSCLC) TRAIL-resistance cells. Int J Biol Sci. 2018 Feb 9;14(2):217-227. doi: 10.7150/ijbs.22811. eCollection 2018.

Zhou H, Mondal A, Dakic A, Alhawas L, Liu X, He Z. Time-Dependent Effects of POT1 Knockdown on Proliferation, Tumorigenicity, and HDACi Response of SK-OV3 Ovarian Cancer Cells. Biomed Res Int. 2018 Feb 6;2018:7184253. doi: 10.1155/2018/7184253. eCollection 2018.

Alamri A, Liu X, Blancato J, Haddad B, Wang W, Zhong X, Choudhary S, Krawczyk E, Kallakury B, Davidson B, Furth P. Expanding primary cells from mucoepidermoid and other salivary gland neoplasms for genetic and chemosensitivity testing. Disease Models & Mechanisms 2018 11: dmm031716 doi: 10.1242/dmm.031716 Published 29 January 2018

Jin L, Qu Y, GomeznL, Chung S, Han B, Gao B, Yue Y, Gong Y, Liu X, Amersi F, Dang C, Giuliano A, Cui X. Characterization of primary human mammary epithelial cells isolated and propagated by conditional reprogrammed cell culture. Oncotarget. 22 December 2017. 

Zhang Y, Dakic A, Chen R, Dai Y, Schlegel R, Liu XDirect HPV E6/Myc interactions induce histone modifications, Pol II phosphorylation, and hTERT promoter activation. Oncotarget. 2017 Oct 25;8:96323-96339. 

Mahajan A, Sugita B, Duttargi A, Saenz F, Krawczyk E, McCutcheon J, Fonseca A, Kallakury B, Pohlmann P, Gusev Y, Cavalli L. Genomic comparison of early-passage conditionally reprogrammed breast cancer cells to their corresponding primary tumors. ​PLoS One. 2017 Oct 19;12(10):e0186190. doi: 10.1371/journal.pone.0186190. eCollection 2017.

Levy BJ, Sample S, Yuan HMultimodal treatment of a dog with disseminated cutaneous viral papillomatosis. Vet Dermatol. 2017 Sep 18. doi: 10.1111/vde.12490. [Epub ahead of print]

Chen CChoudhury S, Wangsa D, Lescott CWilkins DSripadhan PLiu X, Wangsa D, Ried T, Moskaluk C, Wick M, Glasgow E, Schlegel R, and Agarwal SA multiplex preclinical model for adenoid cystic carcinoma of the salivary gland identifies regorafenib as a potential therapeutic drug. Scientific Reports, 2017 Sep 12;7(1):11410. PMID: 28900283.

X Jiang X, Bao Y, Liu H, Kou X, Zhang Z, Sun F, Qian Z, Lin Z, Li X, Liu X, Jian L, Yang Y, VPS34 stimulation of p62 phosphorylation for cancer progression. Oncogene. 2017 August 28; doi:10.1038/onc.2017.295. [Epub ahead of print]

Linder K, Bizikova P, Luff J, Zhou DYuan H, Breuhaus B, Nelson E, Mackay R. Generalized papillomatosis in three horses associated with a novel equine papillomavirus (EcPV8). Vet Dermatol. 2017 Aug 22. doi: 10.1111/vde.12481. [Epub ahead of print]

Suprynowicz F, Kamonjoh C, Krawczyk EAgarwal S, Wellstein A, Agboke F, Choudhury S, Liu X, Schlegel RConditional cell reprogramming involves non-canonical β-catenin activation and mTOR-mediated inactivation of Akt. PloS one. 2017 Jul 10; 12(7):e0180897. PubMed [journal] PMID: 28700668 PMCID: PMC5507294

Yuan H, Krawczyk E, Blancato J, Albanese C, Zhou D, Wang N, Paul S, Alkhilaiwi F, Palechor-Ceron N, Dakic A, Fang S, Choudhary S, Hou TW, Zheng YL, Haddad BR, Usuda Y, Hartmann D, Symer D, Gillison M, Agarwal S, Wangsa D, Ried T, Liu X, Schlegel R. HPV positive neuroendocrine cervical cancer cells are dependent on Myc but not E6/E7 viral oncogenesScientific reports. 2017; 7:45617. PubMed [journal] PMID: 28378747 PMCID: PMC5381214

Horikawa I, Park K, Isogaya K, Hiyoshi Y, Li H, Anami K, Robles A, Mondal A, Fujita K, Serrano M, Harris C. Δ133p53 represses p53-inducible senescence genes and enhances the generation of human induced pluripotent stem cells. Nature. 31 March 2017. doi:10.1038/cdd.2017.48

Liu X, Krawczyk E, Suprynowicz F, Palechor-Ceron N, Yuan H, Dakic A, Simic V, Zheng Y, Sripadhan P, Chen C, Lu J, Hou TW, Choudhury S, Kallakury B, Tang DG, Darling T, Thangapazham R, Timofeeva O, Dritschilo A, Randell SH, Albanese C, Agarwal S, Schlegel RConditional reprogramming and long-term expansion of normal and tumor cells from human biospecimens. Nature protocols. 2017 Feb;12(2):439-451. PubMed [journal] PMID: 28125105

Gentzsch M, Boyles S, Cheluvaraju C, Chaudhry I, Quinney N, Cho C, Dang H, Liu X, Schlegel R, Randell S. Pharmacological Rescue of Conditionally Reprogrammed Cystic Fibrosis Bronchial Epithelial Cells. Am J Respir Cell Mol Biol. 2016 Dec 16. [Epub ahead of print] PMID: 27983869 DOI: 10.1165/rcmb.2016-0276MA

Timofeeva O, Palechor-Ceron N, Li G, Yuan H, Krawczyk E, Zhong X, Liu G, Upadhyay G, Dakic A, Yu S, Fang S, Choudhury S, Zhang X, Ju A, Lee MS, Dan H, Ji Y, Hou Y, Zheng YL, Albanese C, Rhim J, Schlegel R, Dritschilo A, Liu XConditionally reprogrammed normal and primary tumor prostate epithelial cells: a novel patient-derived cell model for studies of human prostate cancer. Oncotarget. 2016 Dec 15.  [Online] 5:0

Dakic A, DiVito K, Fang S, Suprynowicz F, Gaur A, Li X, Palechor Ceron N, Simic V, Choudhury S, Yu S, Simbulan Rosenthal CM, Rosenthal D, Schlegel R, Liu X. ROCK inhibitor reduces Myc induced apoptosis and mediates immortalization of human keratinocytes. Oncotarget. 2016 Aug 20. doi: 10.18632/oncotarget.11458. [Epub ahead of print] PMID: 27556514 DOI: 10.18632/oncotarget.11458.

Wang Z, Liu X, Ho RL, Lam CW, Chow MS. Precision or Personalized Medicine for Cancer Chemotherapy: Is there a Role for Herbal Medicine. Molecules 2016 Jul 7;21(7),  pii: E889; doi:10.3390/molecules21070889. PMID: 27399658.

Chen C, Schlegel R, Agarwal S, Glante P, Penalva L. Functional genomics analyses of RNA-binding proteins reveal the splicing regulator SNRPB as an oncogenic candidate in glioblastoma. Genome Biology. 2016 Jun 10;17(1):125. doi: 10.1186/s13059-016-0990-4. PMID: 27287018 

Alamri A, Kang K, Groeneveld S, Wang W, Zhong X, Kallakury B, Hennighausen L, Liu XFurth PPrimary cancer cell culture: mammary-optimized versus conditional-reprogramming. Endocr Relat Cancer. 2016 June 7, ERC-16-0071. doi: 10.1530/ERC-16-0071. PMID: 27267121

Zhang Y, Lapidus RG, Liu P, Choi EY, Adediran S, Hussain A, Wang X, Liu X, Dan HC. Targeting IκB kinase β/NF-κB signaling in human prostate cancer by a novel IκB kinase β inhibitor CmpdA. Mol Cancer Ther. 2016 Apr 8. pii: molcanther.0999.2015. [Epub ahead of print]

Li Z, Yang Z, Passaniti A, Lapidus RG, Liu X, Cullen KJ, Dan HC. A positive feedback loop involving EGFR/Akt/mTORC1 and IKK/NF-kB regulates head and neck squamous cell carcinoma proliferation. Oncotarget. 2016 Feb 17. doi: 10.18632/oncotarget.7441. [Epub ahead of print] PMID: 

Adams BD, Wali VB, Cheng CJ, Inukai S, Booth CJ, Agarwal S, Rimm DL, Győrffy B, Santarpia L, Pusztai L, Saltzman WM, Slack FJ. miR-34a Silences c-SRC to Attenuate Tumor Growth in Triple Negative Breast Cancer. Cancer Res. 2015 Dec 16. pii: canres.2321.2015. [Epub ahead of print] PMID: 26676753.

Li Z, Yang Z, Lapidus RG, Liu X, Cullen KJ, Dan HC. IKK phosphorylation of NF-κB at serine 536 contributes to acquired cisplatin resistance in head and neck squamous cell cancer. Am J Cancer Res. 2015 Sep 15;5(10):3098-110. eCollection 2015. PMID:26693062

Luff J, Mader M, Britton M, Fass J, Rowland P, Orr C, Schlegel R, Yuan H. Complete genome sequence of canine papillomavirus type 16. Genome Announc. 2015 May 7:3(3). pii: e00404-15. doi: 10.1128/genomeA.00404-15. PMID: 25953189.

Zhou D, Luff J, Paul S, Alkhilaiwi F, Usuda Y, Wang N, Affolter V, Moore P, Schlegel R, Yuan HComplete genome sequence of canine papillomavirus virus type 12. Genome Announc. 2015 Apr 16;3(2). pii: e00294-15. doi: 10.1128/genomeA.00294-15. PMID: 25883294.

Selvanathana S, Grahama G, Erkizana H, Dirksenb U, Natarajanc T, Dakic A, Yu S, Liu X, Paulsene M, Ljungmane M, Wuc C, Lawlorf E, Üren A, Toretsky J. Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing. PNAS. 2015 Mar 3. [Epub ahead of print] doi:10.1073/pnas.1500536112. 

Agarwal S, Hanna J, Sherman ME, Figueroa J, Rimm DL. Quantitative assessment of miR34a as an independent prognostic marker in breast cancer. Br J Cancer. 2015 Jan 6;112(1):61-8. doi: 10.1038/bjc.2014.573. PMID: 25474246. Epub 2014 Dec 4.

Ringer L, Sirajuddin P, Tricoli L, Waye S, Choudhry MU, Parasido E, Sivakumar A, Heckler M, Naeem A, Abdelgawad I, Liu X, Feldman AS, Lee RJ, Wu CL, Yenugonda V, Kallakury B, Dritschilo A, Lynch J, Schlegel R, Rodriguez O, Pestell RG, Avantaggiati ML, Albanese CThe induction of the p53 tumor suppressor protein bridges the apoptotic and autophagic signaling pathways to regulate cell death in prostate cancer cells. Oncotarget. 2014 Sep 26. [Epub ahead of print] PMID: 25296977.

Luff JA, Yuan H, Kennedy D, Schlegel R, Felsburg P, Moore PF. Keratinocyte Antiviral Response to Poly(dA:dT) Stimulation and Papillomavirus Infection in a Canine Model of X-Linked Severe Combined Immunodeficiency. PLoS One. 2014 Jul 15;9(7):e102033. doi: 10.1371/journal.pone.0102033. eCollection 2014. PubMed PMID: 25025687.

Zheng YL, Zhang F, Sun B, Du J, Sun C, Wang Y, Tao L, Kota K, Liu XSchlegel R, Yang Q. Telomerase enzymatic component hTERT shortens long telomeres in human cells. Cell Cycle. 2014 Jun 1;13(11):1765-76. PubMed PMID: 24721976.

Zhou D, Luff J, Usuda Y, Affolter V, Moore P, Schlegel R, Yuan H. Complete genome sequence of canine papillomavirus type 11. Genome Announc. 2014 May 29;2(3). PubMed PMID:24874662.

Saenz FR, Ory V, AlOtaiby M, Rosenfield S, Furlong M, Cavalli LR, Johnson MLiu XSchlegel RWellstein A and Riegel AT. Conditionally reprogrammed normal and transformed mouse mammary epithelial cells display a progenitor-cell–like phenotype. PLoS One. 2014 May 15;9(5):e97666. doi: 10.1371/journal.pone.0097666. eCollection 2014. PubMed PMID: 24831228.

Assefnia S, Kang K, Groeneveld S, Yamaji D, Dabydeen S, Alamri A, Liu X, Hennighausen L, Furth PA. Trp63 is regulated by STAT5 in mammary tissue and subject to differentiation in cancer. Endocr Relat Cancer. 2014 May 6;21(3):443-57. PubMed PMID: 24692510.

Bove PF, Dang H, Cheluvaraju C, Jones LC, Liu X, O'Neal WK, Randell SH, Schlegel R, Boucher RC. Breaking the In-Vitro Alveolar Type II Cell Proliferation Barrier While Retaining Ion Transport Properties. Am J Respir Cell Mol Biol. 2014 Apr;50(4):767-76. PubMed PMID: 24191670.

Pollock CB, McDonough S, Wang VS, Lee H, Ringer L, Liu X, Prandi C, Lee RJ, Feldman AS, Koltai H, Kapulnik Y, Rodriguez OC, Schlegel RAlbanese C,Yarden RI. Strigolactone analogues induce apoptosis through activation of p38 and the stress response pathway in cancer cell lines and in conditionally reprogrammed primary prostate cancer cells. Oncotarget. 2014 Mar 30;5(6):1683-98.PubMed PMID: 24742967.

Palechor-Ceron NSuprynowicz FA, Upadhyay G, Dakic A, Minas T, Simic VJohnson MAlbanese CSchlegel RLiu X. Radiation Induces Diffusible Feeder Cell Factor(s) That Cooperate with ROCK Inhibitor to Conditionally Reprogram and Immortalize Epithelial Cells. Am J Pathol. 2013 Dec;183(6):1862-70. PubMed PMID: 24096078.  

Yuan H, Zhou D, Wang J, Schlegel RDivergent human papillomavirus associated with recurrent respiratory papillomatosis with lung involvement. Genome Announc. 2013 Jul 11;1(4). PMID:23846273.

Nakles RE, Kallakury BV, Furth PA. The PPARγ agonist efatutazone increases the spectrum of well differentiated mammary cancer subtypes initiated by loss of full-length BRCA1 in association with TP53 haploinsufficiency. Am J Pathol. 2013 Jun;182(6):1976-85. PubMed PMID: 23664366.

Miller J, Dakic A, Chen R, Palechor-Ceron N, Dai Y, Kallakury B, Schlegel R, Liu XHPV16 E7 protein and hTERT proteins defective for telomere maintenance cooperate to immortalize human keratinocytes. PLoS Pathog. 2013;9(4):e1003284. doi: 10.1371/journal.ppat.1003284. Epub 2013 Apr 4. PMID: 23592995.

Suprynowicz FA, Upadhyay G, Krawczyk E, Kramer SC, Hebert JD, Liu XYuan H, Cheluvaraju C, Clapp PW, Boucher RC Jr, Kamonjoh CM, Randell SH, Schlegel RConditionally reprogrammed cells represent a stem-like state of adult epithelial cells. Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):20035-40. PubMed PMID:23169653.

Hanna JA, Hahn L, Agarwal S, Rimm DL. In Situ Measurement of miR-205 in Malignant Melanoma Tissue Supports its Role as a Tumor Suppressor MicroRNA. Lab Invest. 2012 Oct;92(10):1390-7. PMID: 22890556.

Yuan H, Myers S, Wang J, Zhou D, Woo JA, Kallakury B, Ju A, Bazylewicz M, Carter YM, Albanese C, Grant N, Shad A, Dritschilo A, Liu X, Schlegel R. Use of Reprogrammed Cells to IdentifyTherapy for Respiratory Papillomatosis. N Engl J Med. 2012 Sep 27;367(13):1220-7. PubMed PMID: 23013073.

Agarwal S, Gertler F, Balsamo M, Condeelis J, Camp R, Xue X, Lin J, Rohan T and Rimm D. Quantitative Assessment of Invasive Mena Isoforms (Menacalc) as an Independent Prognostic Marker in Breast Cancer. Breast Cancer Res. 2012 Sep 12;14(5):R124.. PMID: 22971274.

Sahab Z, Sudarshan SR, Liu X, Zhang Y, Kirilyuk A, Kamonjoh CM, Simic V, Dai Y, Byers SW, Doorbar J, Suprynowicz FA, Schlegel R. Quantitative measurement of human papillomavirus type 16 E5 oncoprotein levels in epithelial cell lines by mass spectrometry. J Virol. 2012 Sep;86(17):9465-73. PubMed PMID: 22740411.

Cabrera MC, Díaz-Cruz ES, Kallakury BV, Pishvaian MJ, Grubbs CJ, Muccio DD, Furth PA. The CDK4/6 inhibitor PD0332991 reverses epithelial dysplasia associated with abnormal activation of the cyclin-CDK-Rb pathway. Cancer Prev Res (Phila). 2012 Jun;5(6):810-21. PubMed PMID: 22508966.

Hanna JA, Wimberly H, Kumar S, Slack F, Agarwal S and Rimm DL. Quantitative analysis of microRNAs in tissue microarrays by in situ hybridization. Biotechniques. 2012 Apr;52(4):235-45. PMID:22482439.

Agarwal S, Rimm DL. Making every cell like HeLa a giant step for cell culture. Am J Pathol. 2012 Feb;180(2):443-5. doi: 10.1016/j.ajpath.2011.12.001. Epub 2011 Dec 20.

Bonilla-Delgado J, Bulut G, Liu X, Cortés-Malagón EM, Schlegel R, Flores-Maldonado C, Contreras RG, Chung SH, Lambert PF, Uren A, Gariglio P. The E6 oncoprotein from HPV16 enhances the canonical Wnt/β-catenin pathway in skin epidermis in vivo. Mol Cancer Res. 2012 Feb;10(2):250-8. doi: 10.1158/1541-7786.MCR-11-0287. Epub 2011 Dec 7. PMID: 22160870.

Liu X, Ory V, Chapman S, Yuan H, Albanese C, Kallakury B, Timofeeva OA, Nealon C, Dakic A, Simic V, Haddad BR, Rhim JS, Dritschilo A, Riegel A, McBride A, Schlegel R. ROCK inhibitor and feeder cells induce the conditional reprogramming of epithelial cells. Am J Pathol. 2012 Feb;180(2):599-607. PubMed PMID: 22189618.

Krawczyk E, Suprynowicz FA, Hebert JD, Kamonjoh CM, Schlegel R. The human papillomavirus type 16 oncoprotein translocates calpactin to the perinuclear region. J Virol. 2011 Nov;85(21):10968-75. PubMed PMID: 21849434.

Díaz-Cruz ES, Sugimoto Y, Gallicano GI, Brueggemeier RW, Furth PA. Comparison of increased aromatase versus ERα in the generation of mammary hyperplasia and cancer. Cancer Res. 2011 Aug 15;71(16):5477-87. PubMed PMID: 21840986.

Suprynowicz FA, Krawczyk E, Hebert JD, Sudarshan SR, Simic V, Kamonjoh CM, Schlegel R. The human papillomavirus type 16 E5 oncoprotein inhibits epidermal growth factor trafficking independently of endosome acidification. J Virol. 2010 Oct;84(20):10619-29. PubMed PMID: 20686024.

Wang J, Zhou D, Prabhu A, Schlegel R, Yuan HThe canine papillomavirus and gamma HPV E7 proteins use an alternative domain to bind and destabilize the retinoblastoma protein. PLoS Pathog. 2010 Sep 2;6(9):e1001089. PMID:20824099.

Díaz-Cruz ES, Furth PA. Deregulated estrogen receptor alpha and p53 heterozygosity collaborate in the development of mammary hyperplasia. Cancer Res. 2010 May 15;70(10):3965-74. PubMed PMID: 20466998.

Neumeister V, Agarwal S, Bordeaux J, Camp RL, Rimm DL. In situ identification of putative cancer stem cells by multiplexing ALDH1, CD44, and cytokeratin identifies breast cancer patients with poor prognosis. Am J Patholo, 2010 May;176(5):2131-8. PMID:20228222.

Liu XDakic A, Zhang Y, Dai Y, Chen R, Schlegel RHPV E6 protein interacts physically and functionally with the cellular telomerase complex. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18780-5. doi: 10.1073/pnas.0906357106. Epub 2009 Oct 20. PMID: 19843693.

Agarwal S, Zerillo C, Kolmakova J, Christensen JG, Harris LN, Rimm DL, DiGiovanna MP, Stern DF. Association of constitutively activated hepatocyte growth factor receptor (Met) with resistance to a dual EGFR/HER2 inhibitor in non-small-cell lung cancer cells. BJC, 2009 March 24;100, 941, PMID:19240716.

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