Publications

Representative Papers from the Past 5 Years

 

Liu XKrawczyk E, Suprynowicz FPalechor-Ceron NYuan H, Dakic ASimic V, Zheng YL, Sripadhan P, Chen C, Lu J, Hou TW, Choudhury S, Kallakury B, Tang D, Darling T, Thangapazham R, Timofeeva O, Dritschilo A, Randell S, Albanese C, Agarwal S, Schlegel RConditional reprogramming and long-term expansion of normal and tumor cells from human biospecimens. Nature Protocols. 26 January 2017. 12, 439–451 (2017) doi:10.1038/nprot.2016.174 Published online. 

Gentzsch M, Boyles S, Cheluvaraju C, Chaudhry I, Quinney N, Cho C, Dang H, Liu X, Schlegel R, Randell S. Pharmacological Rescue of Conditionally Reprogrammed Cystic Fibrosis Bronchial Epithelial Cells. Am J Respir Cell Mol Biol. 2016 Dec 16. [Epub ahead of print] PMID: 27983869 DOI: 10.1165/rcmb.2016-0276MA

Timofeeva O, Palechor-Ceron N, Li G, Yuan H, Krawczyk E, Zhong X, Liu G, Upadhyay G, Dakic A, Yu S, Fang S, Choudhury S, Zhang X, Ju A, Lee MS, Dan H, Ji Y, Hou Y, Zheng YL, Albanese C, Rhim J, Schlegel R, Dritschilo A, Liu XConditionally reprogrammed normal and primary tumor prostate epithelial cells: a novel patient-derived cell model for studies of human prostate cancer. Oncotarget. 2016 Dec 15.  [Online] 5:0

Dakic ADiVito K, Fang SSuprynowicz FGaur A, Li X, Palechor Ceron NSimic V, Choudhury S, Yu S, Simbulan Rosenthal CM,Rosenthal DSchlegel R, Liu XROCK inhibitor reduces Myc induced apoptosis and mediates immortalization of human keratinocytes. Oncotarget. 2016 Aug 20. doi: 10.18632/oncotarget.11458. [Epub ahead of print] PMID: 27556514 DOI: 10.18632/oncotarget.11458. 

Wang Z, Liu X, Ho RL, Lam CW, Chow MS. Precision or Personalized Medicine for Cancer Chemotherapy: Is there a Role for Herbal Medicine. Molecules 2016 Jul 7;21(7),  pii: E889; doi:10.3390/molecules21070889. PMID: 27399658.

Chen C, Schlegel R, Agarwal S, Glante P, Penalva L. Functional genomics analyses of RNA-binding proteins reveal the splicing regulator SNRPB as an oncogenic candidate in glioblastoma. Genome Biology. 2016 Jun 10;17(1):125. doi: 10.1186/s13059-016-0990-4. PMID: 27287018 

Alamri A, Kang K, Groeneveld S, Wang W, Zhong X, Kallakury B, Hennighausen L, Liu XFurth PPrimary cancer cell culture: mammary-optimized versus conditional-reprogramming. Endocr Relat Cancer. 2016 June 7, ERC-16-0071. doi: 10.1530/ERC-16-0071. PMID: 27267121

Zhang Y, Lapidus RG, Liu P, Choi EY, Adediran S, Hussain A, Wang X, Liu X, Dan HC. Targeting IκB kinase β/NF-κB signaling in human prostate cancer by a novel IκB kinase β inhibitor CmpdA. Mol Cancer Ther. 2016 Apr 8. pii: molcanther.0999.2015. [Epub ahead of print]

Li Z, Yang Z, Passaniti A, Lapidus RGLiu X, Cullen KJ, Dan HCA positive feedback loop involving EGFR/Akt/mTORC1 and IKK/NF-kB regulates head and neck squamous cell carcinoma proliferation. Oncotarget. 2016 Feb 17. doi: 10.18632/oncotarget.7441. [Epub ahead of print] PMID: 26895469

Adams BD, Wali VB, Cheng CJ, Inukai S, Booth CJ, Agarwal S, Rimm DL, Győrffy B, Santarpia L, Pusztai L, Saltzman WM, Slack FJ. miR-34a Silences c-SRC to Attenuate Tumor Growth in Triple Negative Breast Cancer. Cancer Res. 2015 Dec 16. pii: canres.2321.2015. [Epub ahead of print] PMID: 26676753.

Li Z, Yang Z, Lapidus RGLiu X, Cullen KJ, Dan HC. IKK phosphorylation of NF-κB at serine 536 contributes to acquired cisplatin resistance in head and neck squamous cell cancer. Am J Cancer Res. 2015 Sep 15;5(10):3098-110. eCollection 2015. PMID:26693062

Luff J, Mader M, Britton M, Fass J, Rowland P, Orr C, Schlegel R, Yuan H. Complete genome sequence of canine papillomavirus type 16. Genome Announc. 2015 May 7:3(3). pii: e00404-15. doi: 10.1128/genomeA.00404-15. PMID: 25953189.

Zhou D, Luff J, Paul S, Alkhilaiwi F, Usuda Y, Wang N, Affolter V, Moore P, Schlegel R, Yuan HComplete genome sequence of canine papillomavirus virus type 12. Genome Announc. 2015 Apr 16;3(2). pii: e00294-15. doi: 10.1128/genomeA.00294-15. PMID: 25883294.

Selvanathana S, Grahama G, Erkizana H, Dirksenb U, Natarajanc T, Dakic A, Yu S, Liu X, Paulsene M, Ljungmane M, Wuc C, Lawlorf E, Üren A, Toretsky J. Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing. PNAS. 2015 Mar 3. [Epub ahead of print] doi:10.1073/pnas.1500536112. 

Agarwal S, Hanna J, Sherman ME, Figueroa J, Rimm DL. Quantitative assessment of miR34a as an independent prognostic marker in breast cancer. Br J Cancer. 2015 Jan 6;112(1):61-8. doi: 10.1038/bjc.2014.573. PMID: 25474246. Epub 2014 Dec 4.

Ringer L, Sirajuddin P, Tricoli L, Waye S, Choudhry MU, Parasido E, Sivakumar A, Heckler M, Naeem A, Abdelgawad I, Liu X, Feldman AS, Lee RJ, Wu CL, Yenugonda V, Kallakury B, Dritschilo A, Lynch J, Schlegel R, Rodriguez O, Pestell RG, Avantaggiati ML, Albanese CThe induction of the p53 tumor suppressor protein bridges the apoptotic and autophagic signaling pathways to regulate cell death in prostate cancer cells. Oncotarget. 2014 Sep 26. [Epub ahead of print] PMID: 25296977.

Luff JA, Yuan H, Kennedy D, Schlegel R, Felsburg P, Moore PF. Keratinocyte Antiviral Response to Poly(dA:dT) Stimulation and Papillomavirus Infection in a Canine Model of X-Linked Severe Combined Immunodeficiency. PLoS One. 2014 Jul 15;9(7):e102033. doi: 10.1371/journal.pone.0102033. eCollection 2014. PubMed PMID: 25025687.

Zheng YL, Zhang F, Sun B, Du J, Sun C, Wang Y, Tao L, Kota K, Liu XSchlegel R, Yang Q. Telomerase enzymatic component hTERT shortens long telomeres in human cells. Cell Cycle. 2014 Jun 1;13(11):1765-76. PubMed PMID: 24721976.

Zhou D, Luff J, Usuda Y, Affolter V, Moore P, Schlegel R, Yuan H. Complete genome sequence of canine papillomavirus type 11. Genome Announc. 2014 May 29;2(3). PubMed PMID:24874662.

Saenz FR, Ory V, AlOtaiby M, Rosenfield S, Furlong M, Cavalli LR, Johnson MLiu XSchlegel RWellstein A and Riegel AT. Conditionally reprogrammed normal and transformed mouse mammary epithelial cells display a progenitor-cell–like phenotype. PLoS One. 2014 May 15;9(5):e97666. doi: 10.1371/journal.pone.0097666. eCollection 2014. PubMed PMID: 24831228.

Assefnia S, Kang K, Groeneveld S, Yamaji D, Dabydeen S, Alamri A, Liu X, Hennighausen L, Furth PA. Trp63 is regulated by STAT5 in mammary tissue and subject to differentiation in cancer. Endocr Relat Cancer. 2014 May 6;21(3):443-57. PubMed PMID: 24692510.

Bove PF, Dang H, Cheluvaraju C, Jones LC, Liu X, O'Neal WK, Randell SH, Schlegel R, Boucher RC. Breaking the In-Vitro Alveolar Type II Cell Proliferation Barrier While Retaining Ion Transport Properties. Am J Respir Cell Mol Biol. 2014 Apr;50(4):767-76. PubMed PMID: 24191670.

Pollock CB, McDonough S, Wang VS, Lee H, Ringer L, Liu X, Prandi C, Lee RJ, Feldman AS, Koltai H, Kapulnik Y, Rodriguez OC, Schlegel RAlbanese C,Yarden RI. Strigolactone analogues induce apoptosis through activation of p38 and the stress response pathway in cancer cell lines and in conditionally reprogrammed primary prostate cancer cells. Oncotarget. 2014 Mar 30;5(6):1683-98.PubMed PMID: 24742967.

Palechor-Ceron NSuprynowicz FA, Upadhyay G, Dakic A, Minas T, Simic VJohnson MAlbanese CSchlegel RLiu X. Radiation Induces Diffusible Feeder Cell Factor(s) That Cooperate with ROCK Inhibitor to Conditionally Reprogram and Immortalize Epithelial Cells. Am J Pathol. 2013 Dec;183(6):1862-70. PubMed PMID: 24096078.  

Yuan H, Zhou D, Wang J, Schlegel RDivergent human papillomavirus associated with recurrent respiratory papillomatosis with lung involvement. Genome Announc. 2013 Jul 11;1(4). PMID:23846273.

Nakles RE, Kallakury BV, Furth PA. The PPARγ agonist efatutazone increases the spectrum of well differentiated mammary cancer subtypes initiated by loss of full-length BRCA1 in association with TP53 haploinsufficiency. Am J Pathol. 2013 Jun;182(6):1976-85. PubMed PMID: 23664366.

Miller J, Dakic A, Chen R, Palechor-Ceron N, Dai Y, Kallakury B, Schlegel R, Liu XHPV16 E7 protein and hTERT proteins defective for telomere maintenance cooperate to immortalize human keratinocytes. PLoS Pathog. 2013;9(4):e1003284. doi: 10.1371/journal.ppat.1003284. Epub 2013 Apr 4. PMID: 23592995.

Suprynowicz FA, Upadhyay G, Krawczyk E, Kramer SC, Hebert JD, Liu XYuan H, Cheluvaraju C, Clapp PW, Boucher RC Jr, Kamonjoh CM, Randell SH, Schlegel RConditionally reprogrammed cells represent a stem-like state of adult epithelial cells. Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):20035-40. PubMed PMID:23169653.

Hanna JA, Hahn L, Agarwal S, Rimm DL. In Situ Measurement of miR-205 in Malignant Melanoma Tissue Supports its Role as a Tumor Suppressor MicroRNA. Lab Invest. 2012 Oct;92(10):1390-7. PMID: 22890556.

Yuan H, Myers S, Wang J, Zhou D, Woo JA, Kallakury B, Ju A, Bazylewicz M, Carter YM, Albanese C, Grant N, Shad A, Dritschilo A, Liu X, Schlegel R. Use of Reprogrammed Cells to IdentifyTherapy for Respiratory Papillomatosis. N Engl J Med. 2012 Sep 27;367(13):1220-7. PubMed PMID: 23013073.

Agarwal S, Gertler F, Balsamo M, Condeelis J, Camp R, Xue X, Lin J, Rohan T and Rimm D. Quantitative Assessment of Invasive Mena Isoforms (Menacalc) as an Independent Prognostic Marker in Breast Cancer. Breast Cancer Res. 2012 Sep 12;14(5):R124.. PMID: 22971274.

Sahab Z, Sudarshan SR, Liu X, Zhang Y, Kirilyuk A, Kamonjoh CM, Simic V, Dai Y, Byers SW, Doorbar J, Suprynowicz FA, Schlegel R. Quantitative measurement of human papillomavirus type 16 E5 oncoprotein levels in epithelial cell lines by mass spectrometry. J Virol. 2012 Sep;86(17):9465-73. PubMed PMID: 22740411.

Cabrera MC, Díaz-Cruz ES, Kallakury BV, Pishvaian MJ, Grubbs CJ, Muccio DD, Furth PA. The CDK4/6 inhibitor PD0332991 reverses epithelial dysplasia associated with abnormal activation of the cyclin-CDK-Rb pathway. Cancer Prev Res (Phila). 2012 Jun;5(6):810-21. PubMed PMID: 22508966.

Hanna JA, Wimberly H, Kumar S, Slack F, Agarwal S and Rimm DL. Quantitative analysis of microRNAs in tissue microarrays by in situ hybridization. Biotechniques. 2012 Apr;52(4):235-45. PMID:22482439.

Agarwal S, Rimm DL. Making every cell like HeLa a giant step for cell culture. Am J Pathol. 2012 Feb;180(2):443-5. doi: 10.1016/j.ajpath.2011.12.001. Epub 2011 Dec 20.

Bonilla-Delgado J, Bulut G, Liu X, Cortés-Malagón EM, Schlegel R, Flores-Maldonado C, Contreras RG, Chung SH, Lambert PF, Uren A, Gariglio P. The E6 oncoprotein from HPV16 enhances the canonical Wnt/β-catenin pathway in skin epidermis in vivo. Mol Cancer Res. 2012 Feb;10(2):250-8. doi: 10.1158/1541-7786.MCR-11-0287. Epub 2011 Dec 7. PMID: 22160870.

Liu X, Ory V, Chapman S, Yuan H, Albanese C, Kallakury B, Timofeeva OA, Nealon C, Dakic A, Simic V, Haddad BR, Rhim JS, Dritschilo A, Riegel A, McBride A, Schlegel R. ROCK inhibitor and feeder cells induce the conditional reprogramming of epithelial cells. Am J Pathol. 2012 Feb;180(2):599-607. PubMed PMID: 22189618.

Krawczyk E, Suprynowicz FA, Hebert JD, Kamonjoh CM, Schlegel R. The human papillomavirus type 16 oncoprotein translocates calpactin to the perinuclear region. J Virol. 2011 Nov;85(21):10968-75. PubMed PMID: 21849434.

Díaz-Cruz ES, Sugimoto Y, Gallicano GI, Brueggemeier RW, Furth PA. Comparison of increased aromatase versus ERα in the generation of mammary hyperplasia and cancer. Cancer Res. 2011 Aug 15;71(16):5477-87. PubMed PMID: 21840986.

Suprynowicz FA, Krawczyk E, Hebert JD, Sudarshan SR, Simic V, Kamonjoh CM, Schlegel R. The human papillomavirus type 16 E5 oncoprotein inhibits epidermal growth factor trafficking independently of endosome acidification. J Virol. 2010 Oct;84(20):10619-29. PubMed PMID: 20686024.

Wang J, Zhou D, Prabhu A, Schlegel R, Yuan HThe canine papillomavirus and gamma HPV E7 proteins use an alternative domain to bind and destabilize the retinoblastoma protein. PLoS Pathog. 2010 Sep 2;6(9):e1001089. PMID:20824099.

Díaz-Cruz ES, Furth PA. Deregulated estrogen receptor alpha and p53 heterozygosity collaborate in the development of mammary hyperplasia. Cancer Res. 2010 May 15;70(10):3965-74. PubMed PMID: 20466998.

Neumeister V, Agarwal S, Bordeaux J, Camp RL, Rimm DL. In situ identification of putative cancer stem cells by multiplexing ALDH1, CD44, and cytokeratin identifies breast cancer patients with poor prognosis. Am J Patholo, 2010 May;176(5):2131-8. PMID:20228222.

Liu XDakic A, Zhang Y, Dai Y, Chen R, Schlegel RHPV E6 protein interacts physically and functionally with the cellular telomerase complex. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18780-5. doi: 10.1073/pnas.0906357106. Epub 2009 Oct 20. PMID: 19843693.

Agarwal S, Zerillo C, Kolmakova J, Christensen JG, Harris LN, Rimm DL, DiGiovanna MP, Stern DF. Association of constitutively activated hepatocyte growth factor receptor (Met) with resistance to a dual EGFR/HER2 inhibitor in non-small-cell lung cancer cells. BJC, 2009 March 24;100, 941, PMID:19240716.